AdverseOutcomePathway

https://ontology.toxindex.com/v1/AdverseOutcomePathway AOP

A sequence of causally linked key events, beginning with a molecular initiating event and ending in an adverse outcome relevant to risk assessment. Key events and their relationships are shared across pathways; a pathway names the ones it assembles and the roles they play in it, so overlapping pathways form a network.

Relationships

References

key_events KeyEvent []

molecular_initiating_events KeyEvent []

adverse_outcomes KeyEvent []

key_event_relationships KeyEventRelationship []

stressors Stressor []

taxa Taxon []

Properties

Class properties with name, type, requirements, and description
Name	Type		Description
`aop_id`	uri	required identifier	IRI of an adverse outcome pathway: its identifiers.org IRI (https://identifiers.org/aop/{id}) when it is registered in the AOP-Wiki, otherwise a minted IRI.
`title`	string	required
`description`	string
`key_events`	KeyEvent []		Every key event a pathway assembles, whatever its role.
`molecular_initiating_events`	KeyEvent []		The key events that start a pathway: the initial interaction between a stressor and a biological target.
`adverse_outcomes`	KeyEvent []		The key events that end a pathway: outcomes relevant to risk assessment or regulatory decision-making.
`key_event_relationships`	KeyEventRelationship []		The causal links a pathway assembles between its key events.
`stressors`	Stressor []		Agents known to trigger a pathway.
`sexes`	SexEnum []		Sexes for which a pathway, key event, or relationship holds.
`taxa`	Taxon []		The taxa for which a pathway, key event, or relationship holds.